An attempt was studied the changes of the activities of superoxide dismutase (EC 1.15.1.1, SOD), catalase (EC. 1.11.1.6), peroxidase (EC 1.11.1.7) and xanthine oxidase (EC 1,1.3.22) in the brains of rats which were treated either with prednisone (10mg/100g body weight, group A) alone or with liposomal superoxide dismutase (3,000 units) followed by prednisone (10mg/100g body weight, group B).
The results were summarized as follows:
1. In most of experimental group A, activity of Cu, Zn-SOD was higher than that in the control; k but group B showed lower than that in the control (P<0.01).
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2. The activity of Mn-SOD in the group A was similar to that in control, and in group B was
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higher than that in the control (p<0.05, p<0.01).
3. I´n most of experimental groups, the catalase activity was similar to that in control
4. The activity of peroxicase in most of experimental groups A was higher than that in the control (p<0. 01), and activity in group A except 1 st day appeared to be higher than that in group B (p<0. 05,
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5. In all experimental groups, xanthine oxidase activity was similar to that in control or decreased.
From the above results, it appeared that prednisone administration could enhance the activity of SOD´ and peroxidase. Accordingly, it could be suggested that prednisone induced oxygen toxicity in rat brain, and SOD and peroxidase, the scavengers of oxygen radicals, may play an important role in defence mechanism of rat brain.
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